Psilocybin is a potent serotonin agonist, so it’s better to avoid if you’re taking any medications
which alter the serotonin system such as SSRI/SNRI antidepressants.
Psilocybin should not be mixed with pain medications such as Tramadol which can lead to serotonin syndrome.
Do not take psilocybin if you’re on antipsychotics, or you have a history of psychosis or schizophrenia.
Please do not mix psilocybin with amphetamines or recreational drugs.
Psilocybin could possibly increase the effects of cannabis.
When you’re in doubt about safety and interactions with a medication that you’re taking, please consult your doctor first.
James Fadiman shares an important precaution about microdosing:
“We specifically do not recommend that people with colorblindness, who live with diagnoses of psychotic disorders or along the autism spectrum try microdosing. People with colorblindness report lasting visual distortions from microdosing. Literature suggests people with psychotic disorders may be harmed by psychedelics. In our experience, people with diagnoses along the autism spectrum seem to require dosages that far exceed what is traditionally considered microdosing.”