Paul Stamets, one of the world’s leading mycologists, developed what is now known as the Stamets Stack—a microdosing protocol designed to support brain health, creativity, and overall well-being. Unlike some other approaches, the Stamets Stack combines psilocybin mushrooms, Lion’s Mane mushroom, and niacin (Vitamin B3) for a synergistic effect on the nervous system and neurogenesis (the growth of new brain cells).
The Core Ingredients
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Psilocybin mushrooms: ~100 mg dried mushrooms per microdose (this may vary depending on sensitivity; always start low).
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Lion’s Mane mushroom: 500–1,000 mg, sometimes up to 2,000 mg per day.
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Niacin (Vitamin B3): 50–100 mg, enough to create a warm “flush.”
Why Niacin?
Stamets intentionally included niacin because the flushing effect increases blood flow, helping to deliver psilocybin and Lion’s Mane compounds more effectively throughout the nervous system. This distribution may enhance their ability to repair and stimulate new neural pathways.
The Schedule
The Stamets Stack is typically followed as:
4 days on, 3 days off
This cycle allows for consistent benefits while giving the body time to reset and avoid building tolerance.
Reported Benefits
Those who follow the Stamets Stack often describe:
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Enhanced creativity & problem-solving
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Improved mental clarity and focus
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Greater emotional balance and resilience
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Long-term brain health support through neurogenesis
How It Differs From Other Protocols
While the Fadiman Protocol (another well-known approach) emphasizes subtle mood support and long-term balance, the Stamets Stack is especially focused on neurogenesis and cognitive enhancement. Both methods have their place, and it’s about finding what feels aligned for your needs.
A Note on SoulCybin’s Approach
The original Stamets Stack, created by Paul Stamets, includes niacin (Vitamin B3) alongside psilocybin and Lion’s Mane. Because niacin is part of a patented protocol, SoulCybin does not include it in our offerings.
Instead, we’ve created blends that honor the spirit of the stack while using natural alternatives to support synergy and absorption:
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Brain Booster – “Mental Mastery”
Combines our SoulCybin Proprietary Blend of psilocybin mushrooms with Lion’s Mane for cognitive clarity and neural support. -
Brain Booster Plus – “Think Fast”
Includes psilocybin mushrooms, Lion’s Mane, plus cacao extract (heart-opening, supportive of absorption) and cayenne extract (gentle circulatory stimulant).
These blends provide a similar synergy of psilocybin + Lion’s Mane, with added plant allies that support energy, focus, and mental clarity — all while staying true to SoulCybin’s unique formulations.
A Gentle Reminder
Every system is unique. If you explore the Stamets Stack, begin with the lowest possible dose to understand your body’s response. Microdosing is about supporting subtle shifts over time, not chasing a high.
For more detailed support, you can explore our Free Microdosing Guide or book a consultation call for personalized guidance: soulcybin.org/consultation-calls